Postgraduate Associate position in receptor pharmacology (Alon Lab)

The Alon lab in the Department of Pharmacology at Yale Medical School and has an open position for an

outstanding and passionate post-grad scientist. Our lab focuses on understudied membrane receptors

implicated in human disease. We use a combination of structural biology, biochemistry, ligand discovery,

and pharmacology to study sigma receptors and other sterol binding proteins as drug targets for

conditions such as cancer and neuropathic pain. We are seeking highly motivated candidates with

excellent organizational skills that can carry out experiments independently.

Training:

Depending on your scientific interest, you will have the opportunity to tackle several projects by applying

a broad range of structural, biochemical, and biophysical techniques to interesting and medically relevant

membrane receptor proteins. You will leverage modern protein purification techniques, structural

techniques such as cryoEM and X-ray crystallography, computational modeling, and CRISPR/Cas9

technology. You will learn basic lab skills such as tissue culture cell maintenance, drug binding assays,

organizing databases, and preparing stock solutions. You will design and execute experiments, analyze

results, and generate figures. You will be a co-author on papers related to your research project.

Mentoring:

Lab members will receive mentoring tailored to their career

goals. You will work closely with Dr. Alon and other lab

members, providing ample learning and growth

opportunities for those interested in biomedical research.

Education:

By the beginning of the appointment, the ideal candidate has completed a bachelor’s and/or master’s

degree in biology, engineering, or another science-related field. The position is ideal for recent graduates

interested in strengthening their research experience prior to applying to medical and/or graduate school.

Previous experience in basic science research and demonstrated record of academic achievement is a

strong plus. Experience with basic molecular biology techniques such as PCR, DNA cloning, and

construct design preferred.

We are seeking candidates who can provide a minimum one-year commitment.

The position is available on a rolling basis until filled. Please send a single PDF with a cover letter

describing interest in the position, CV, and contact information of two references Dr. Assaf Alon

(assaf.alon@yale.edu)