Research Scientist

Job Description: Research Scientist – Mantle Therapeutics, New York City

Position Summary:
Mantle Therapeutics is a biotechnology company based in New York City, seeking a highly motivated and experienced Full-Time Research Scientist to join our team focused on several therapeutic modalities in the treatment of rare fatal diseases. 

The ideal candidate will be comfortable working independently and alongside our Chief Scientific Officer, with expertise in molecular biology and proteomics. Experience in mammalian cell culture (including iPSC), qRT-PCR, ddPCR, ELISA and Western blot techniques is highly desired.

The successful candidate will play a critical role in developing novel therapeutics by executing experimental protocols, analyzing data, and contributing to scientific publications and presentations.

Key Responsibilities:

• Wet-bench: 
  • Gene expression: design, optimize, and perform gene expression measurements via qRT-PCR and ddPCR (where necessary).
  • Protein expression: optimize and establish commercial techniques (western blot & ELISA) to quantify target proteins, ensuring quality and reproducibility.
    • Proteomics experience will be regarded highly (but not required).
  • Lab management: Maintain inventory of laboratory reagents, ordering of required consumables.
• Cell Culture: 
  • Maintain, passage, and manipulate (small-molecule screens, mammalian cell lines. Work will involve primary cell lines, stem-cell lines and differentiation to neurons.
  • Candidates with iPSC handling experience are strongly preferred.
• Data Analysis: Analyze experimental data using statistical tools, document findings, and generate detailed reports for internal review.
• Collaboration: Work closely with cross-functional teams, including Mantle’s executive team to support ongoing projects.
• Compliance & Safety: Follow laboratory protocols, ensure compliance with safety regulations, and contribute to maintaining a well-organized laboratory environment.
• Communication: Present research findings in team meetings and contribute to scientific publications and conference presentations.

Qualifications:

• Education: PhD in Biology, Molecular Biology, Biochemistry, Biotechnology, or a related field. We will strongly consider MS level applicants with considerable stem-cell experience.
• Experience: 3+ years of hands-on research experience, preferably in a pharmaceutical, biotech, or academic setting.
• Technical Skills:
  • Proficient in qRT-PCR and ddPCR techniques for precise nucleic acid quantification.
  • Strong knowledge of ELISA and Western blot protocols for protein detection and analysis.
  • Mammalian primary and stem-cell culture, neuronal differentiation and maintenance
• Analytical Tools: Familiarity with statistical software (e.g., GraphPad Prism) for data analysis and visualization.
• Soft Skills: Excellent problem-solving abilities, strong communication skills, and the ability to work independently and as part of a team.

Preferred Skills:

• Experience with CRISPR-based gene editing or RNA interference (RNAi) techniques.
• Knowledge of immunoassays and antibody validation methods.
• Knowledge of small molecule chemical design and synthesis.
• Bioinformatics experience including analysis of RNA-seq data.

Why Join Mantle Therapeutics?

• Transform Lives with Purpose: Lead the research of various therapeutics targeting rare and life-threatening diseases.
• Innovate at the Cutting Edge: Work in a fast-paced, dynamic environment that pioneers therapeutic breakthroughs.
• Join Scientific Leaders: Collaborate with a world-class team of experts and trailblazers at the forefront of science and medicine.
• Growth Opportunities: Potential for full-time employment with access to benefits such as health insurance and PTO upon conversion.

Location: New York City, NY
Job Type: In-person / Hybrid, Full-Time 
Pay Range: $80-$140k (based on experience and qualifications).