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Research Assistant - Hematopoietic stem cells and blood cancer

Research Technician (Assistant) – Hematopoietic stem cells and leukemia

Job Description

The Children’s Hospital of Philadelphia (CHOP) and University of Pennsylvania School of Medicine (Upen) is dedicated to the understanding, development, and application of gene and protein function in human diseases and the promotion of professional and public education in the field. CHOP fosters a multidisciplinary approach among researchers and scientists working to discover new gene and cell therapies in search of cures for debilitating and life-threatening disorders. The Tong Laboratory, an integral part of CHOP Hematology/Oncology divisions, studies blood development, stem cell expansion, in relevance to bone marrow failure syndromes and leukemias.

A research technician position is available in the Ton lab to investigate hematopoietic stem cells and leukemia. Hematopoietic stem cells give rise to all circulating blood cells throughout life. Maintenance of stem cell self-renewal, proliferation and differentiation is regulated by complex signaling pathways. Aberrant regulation leads to bone marrow failure or leukemia. Dr. Tong’s laboratory studies various signaling pathways in hematopoietic stem cells, bone marrow failure, and leukemia. Her laboratory recently identified a novel E3 ubiquitin ligase that plays a critical role in ribosome assembly and thereby controls hematopoietic stem cell regeneration. This research position will focus on studying the mechanisms by which ubiquitin-dependent signaling and ribosome biogenesis in regulating stem cells and investigating how failures in these processes impact hematopoietic stem cell function that leads to bone marrow failure and/or leukemia. Furthermore, this position will also facilitate to perform state-of-the-art CRISPR/Cas9 screens to identify novel therapeutic targets for treating hematopoietic stem cell diseases.

Our recent publications include: Cell Stem Cell, 28(7):1275-129, 2021; Blood Jun, 2021 &2019; Nature communications 9:3915, 2018; Genes & development 31(10): 1007-1023, May 2017; Blood 133(14): 1560-1571, Apr 2019. JCI, 2008, 2012, 2016. You can find more of our recent publication and laboratory information in below website.

Candidates should have a B.S. or equivalent degree and experience with investigating biochemistry, cell biology, molecular biology, and preferred experience in mouse models. The technician will be trained in tissue culture work, molecular cloning, mouse genetics, and proteomics. Prior experience in any of these specialties is a plus. 

Highly motivated candidates with publication records are encouraged to apply. Please email or send applications with a brief statement of research experience and interest, CV, and contact information for at least two references to:

Wei Tong, PhD

Distinguished Chair in Pediatric Hematology,

Professor of Pediatrics,

Children's Hospital of Philadelphia,

University of Pennsylvania School of Medicine,

Co-Director, Hematopoietic Stem Cell program, 

Institute for Regenerative Medicine at UPENN

Abramson Bldg. 310D,

3615 Civic Center Blvd.,

Philadelphia, PA 19104

Tel: 267-426-0930