Bioproduction Technologist I

Bioproduction Technologist I

Reports to: VP of Manufacturing

Salary Range: $52,000 - $67,000

Type of position: Full-time

Salary Classification: Exempt

General Job Description

Vyriad is a clinical stage biotechnology company based in Rochester MN. We are developing the next generation of targeted genetic medicines for cancer therapy. The Bioproduction Technologist will be responsible for upstream and/or downstream process development and GMP manufacturing of oncolytic viruses, lentiviral vectors and other biologics for clinical trials. The Bioproduction Technologist plays a vital role in the day-to-day process development projects and manufacturing operations in compliance with cGMP standards. Virus and gene therapy manufacturing operations involve aseptic processing in a pharmaceutical cleanroom facility, large-scale cell culture in shake flasks and bioreactors, vector generation, purification, concentration, and fill and finish operations, according to established standard operating procedures (SOPs). In addition, staff are responsible for the daily operations and environmental monitoring of the GMP facility to ensure compliance with applicable regulations. 

Supervisory Responsibilities

None

Duties and Responsibilities

• Performs all aspects of cGMP manufacturing of clinical grade viruses and viral vectors following established SOPs.
• Performs preclinical grade viral vector production, scale-up and process development.
• Reviews, edits, completes and revises batch records, worksheets and SOPs in accordance with Good Document practices. 
• Prepares reagents and ensures inventory for the manufacture of clinical and preclinical viral vectors.
• Performs set up, dismantling, and maintenance of equipment and ensures equipment is ready for production operations.
• Performs manufacturing level maintenance on equipment. 
• Participates in equipment installation, commissioning and validation.
• Maintains manufacturing equipment and records.
• Participates in quality control testing of clinical and preclinical grade vectors. 
• Assists with facility cleaning, changeover, and staging of materials.
• Collaborates closely with the process development, Quality Control and Quality Assurance teams.

Other Responsibilities:

• Practices and promotes safe work habits and adheres to safety procedures and guidelines.
• Provide technical representation during internal and external audits.
• Keeps up to date with current technologies and trends in drug product processing.
• Perform routine tasks including general housekeeping, equipment monitoring, and maintenance.
• Perform additional duties as assigned.

Education and Experience Requirements

• Life sciences degree (Bachelors) in Scientific, Engineering or Healthcare subject area. 
• 1-2 years experience with upstream and/or downstream process development and/or manufacturing and testing of biologics under cGMP compliance.
• Viral vector production experience required 

Required Skills and/or Qualifications

• Ability to apply scientific principles utilized to solve operational, as well as routine production tasks.
• Excellent documentation skills including comprehension, review and establishing Batch Production Records, SOPs, deviations and summary reports.

Physical Requirements

• Prolonged periods of standing at laboratory benches.
• Prolonged periods of sitting at a desk and working on a computer.
• Must be able to lift up to 15 pounds at times.

Benefits

• Group Healthcare Plan, including company paid dental and vision.
• Short- and long-term disability, life and AD&G insurance.
• Simple IRA with employer match
• Educational assistance program
• Holiday and PTO 

Vyriad is an equal opportunity employer and does not discriminate on the basis of race, color, religion, sex, national origin, age, disability, genetic information, gender identity, sexual orientation, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local laws.

This policy applies to all terms and conditions of employment, including, but not limited to, hiring, promotion, termination, layoff, recall, transfer, leaves of absence, compensation, and training.